Thursday, 2 January 2014

Info about Antidepressant medications

The authors [Coca et al, 1996] believe that the antidepressant effect of TMS is intrinsic rather than a possible trigger for the action of antidepressant drugs.
Trigs et al [1999], in an open study of rams over the left prefrontal cortex 10 patients with drug-resistant major depression, daily sessions conducted EMT (2000 stimuli 20 Hz, 80% LM) for 10 days for each patient.  http://forum.dutchfitness.com/showthread.php?p=61627#post61627
Antidepressant medications were reduced and discontinued for a week before the start of TMS.
 The TMS treatment was associated with a significant improvement in mood, including a 41% reduction in HAM-D score and 40% in the BDI. Five patients could be classified as responders, defined by a reduction of at least 50% of the HAM-D after application of MTS.
The improvement in the BDI scale in 10 patients was still statistically significant after 3 months of application of EMT.
 Although this was an open study, without the use of placebo, all patients were resistant to drug therapy, in which two periods of 4 weeks with antidepressants had resulted in failure.
With TMS, all answered well without antidepressant.
Avery et al [1999], in a study of real and placebo TMS over the left prefrontal cortex in the treatment of 6 patients with pharmacologically resistant depression used the following paradigms: 80% LM 10 Hz with 1,000 pulses in 10 sessions over a period of 16 days.  http://forum.dutchfitness.com/showthread.php?p=61628#post61628
The selected patients had had failed at least two different types of antidepressant. Despite the small sample, the authors concluded that the improvement in the group receiving rTMS (down from 10.5 in Hamilton scale) were significant.

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