Structural neuron imaging studies (CT and MRI) and functional (SPECT and PET) also found significant relationships between abnormalities in the prefrontal lobe in both primary depression and secondary depression [George et al, 1994].
Baxter et al [1985] found a decreased metabolism in the left doors lateral prefrontal cortex in all forms of depression and an inverse correlation between the severity of depression and decreased frontal metabolism. Bench et al [1995] reported the changing pattern in the cerebral circulation in a group of 25 patients treated for depression. http://forum.maternal.com.au/viewtopic.php?f=42&t=211947
They compared the cerebral blood flow pre-and post-treatment and reported that an improvement in depression was associated with a significant increase in cerebral blood flow in the cortex left doors lateral prefrontal (DLPFC), including the anterior cingulated gyros.
Stimulation of the DLPFC is reached as follows: First, the researcher sets the correct position of the coil to stimulate the first interosseous muscle or short abductor of the thumb, with the help of these muscles and electroencephalographic electrodes will monitor.
After choosing the best point, the DLPFC is located five cm above the best point of stimulation soon abductor [Pascal-Leone et al, 1996].
However, this method can be more accurately located through the use of stereotactic navigation that allows placement of the coil TMS in individual brain structures recognized after 3D reconstruction by MRI. Clinical Trials: TMS over the left prefrontal cortex several studies have been undertaken in order to assess the true efficacy of TMS in the treatment of depression. http://www.chiliving.com/forum/viewthread/13322/
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