Patients with resistant depression

Some of these studies have shown great efficacy, one of them showing a 50% drop in the Hamilton scale after treatment, even considering that the sample is small and the variability in the parameters used between different protocols is great.
 However, modest effects were also found, even the lack of difference between placebo and real EMT, suggesting a placebo effect for EMT. However, the modest results were found in studies with small number of subjects and with fewer pulses applied by patients.
1) Studies with Large Pro Evidence TMS in the Treatment of Depression. Pascal-Leone et al [1996] conducted an early study TMS randomized for treatment of depression.  http://www.chiliving.com/forum/viewthread/13311/
The authors stimulated different regions and obtained better results in the left prefrontal cortex, despite the short duration of effects.
Coca et al [1996] published an open study with positive results after the use of TMS as an additive therapy for depression, although they used TMS single pulse instead of TMS.
Subsequently, Trigs et al [1999] and Avery et al [1999] stimulating only the left prefrontal cortex impressive results were obtained, achieving greater than 50% reduction in Hamilton scale in half of the patients [Trigs et al, 1999], and with lasting effect -. http://www.c2forum.com/viewforum.php?f=9 longer than 1 year in 1 patient [Avery et al 1999] Paschal-Leone et al [1996], in a randomized study with use of placebo, evaluated 17 patients with resistant depression psychotic subtype
RTMS and sham TMS applied over the vertex, left cortex and door so lateral prefrontal right to 10Hz, with 2,000 pulses per session at an intensity 90% of motor threshold (MT).